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Úplná strukturovaná bibliografie pro habilitační řízení Mgr. Zbyněk Heger, Ph.D. ResID-1973-2013, ORCID 0000-0002-3915-7270

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Úplná strukturovaná bibliografie pro habilitační řízení Mgr. Zbyněk Heger, Ph.D.

ResID-1973-2013, ORCID 0000-0002-3915-7270

Kapitoly v monografiích

1) Rodrigo M. A. M., Anjum N. A., Heger Z., Zitka O., Adam V., Pereira E., Kizek R. (2016) Role of phytochelatins in redox caused stress in plants and animals. in: Abiotic and Biotic Stress in Plants – Recent Advances and Future Perspectives (Shanker A. K., Shanker C. eds.) IntechOpen, London, 395-410.

2) Dostalova S., Heger Z., Kudr J., Vaculovicova M., Adam V., Stiborova M., Eckschlager T., Kizek R.

(2015) Apoferritin: Protein nanocarrier for targeted delivery. in: Nano Based Drug Delivery (Naik J. ed.) IAPC OBP, Zagreb, 217-238.

3) Eckschlager T., Ruttkay-Nedecky B., Heger Z., Hrabeta J., Stiborova M., Adam V., Kizek R. (2015) Metallomics of brain tumors – New diagnostic and therapeutic possibilities. in: Horizons in Cancer Research (H. S. Watanabe ed.) Nova Science Publishers, New York, X-X.

Původní články v časopisech s IF

1) Tesarova B., Dostalova S., Smidova V., Goliasova Z., Skubalova Z., Michalkova H., Hynek D., Michalek P., Polanska H., Vaculovicova M., Hacek J., Eckschlager T., Stiborova M., Pires A. S., Neves A. R. M., Abrantes A. M., Rodrigues T., Matafome P., Botelho M. F., Teixeira P., Mendes F., Heger Z. (2020) Surface-PASylation of ferritin to form stealth nanovehicles enhances in vivo therapeutic performance of encapsulated ellipticine. Applied Materials Today. In press.

IF 8,013

2) Milosavljevic V., Jamroz E., Gagic M., Haddad Y., Michalkova H., Balkova R., Tesarova B., Moulick A., Heger Z., Richtera L., Kopel P., Adam V. (2020) Encapsulation of doxorubicin in furcellaran/chitosan nanocapsules by layer-by-layer technique for selectively controlled drug delivery. Biomacromolecules. In press.

IF 5,667

3) Michalkova H., Skubalova Z., Sopha H., Strmiska V., Tesarova B., Dostalova S., Svec P., Hromadko L., Motola M., Macak J. M., Adam V., Heger Z. (2020) Complex cytotoxicity mechanism of bundles formed from self-organised 1-D anodic TiO2 nanotubes layers. Journal of Hazardous Materials. 388, art. no. 122054.

IF 7,650

4) Jimenez A. M. J., Moulick A., Bhowmick S., Strmiska V., Gagic M., Horakova Z., Kostrica R., Masarik M., Heger Z., Adam V. (2019) One-step detection of human papilloma virus using quantum dot-nucleotide interaction specificity. Talanta. 205, UNSP 120111.

IF 4,916

5) Skubalova Z., Michalkova H., Michalek P., Strmiska V., Guran R., Rodrigo M. A. M., Castkova K., Hynek D., Pekarik V., Zitka O., Adam V., Heger Z. (2019) Prevalent anatase crystalline phase increases the cytotoxicity of biphasic titanium dioxide nanoparticles in mammalian cells. Colloids and Surfaces B-Biointerfaces. 182, UNSP 110391.

IF 3,973

(2)

6) Jelinkova P., Mazumdar A., Sur V. P., Kociova S., Dolezelikova K., Jimenez A. M. J., Koudelkova Z., Mishra P. K., Smerkova K., Heger Z., Vaculovicova M., Moulick A., Adam V. (2019) Nanoparticle-drug conjugates treating bacterial infections. Journal of Controlled Release. 307, 166-185.

IF 7,901

7) Indra R., Pompach P., Martinek V., Takacsova P., Vavrova K., Heger Z., Adam V., Eckschlager T., Kopeckova K., Arlt V. M., Stiborova M. (2019) Identification of human enzymes oxidizing the anti-thyroid-cancer drug vandetanib and explanation of the high efficiency of cytochrome P450 3A4 in its oxidation. International Journal of Molecular Sciences. 20, art. no. 3392.

IF 4,183

8) Haddad Y., Adam V., Heger Z. (2019) Rotamer dynamics: Analysis of rotamers in molecular dynamics simulation of proteins. Biophysical Journal. 116, 2062-2072.

IF 3,665

9) Strmiska V., Michalek P., Lackova Z., Guran R., Krizkova S., Vanickova L., Zitka O., Stiborova M., Eckschlager T., Klejdus B., Pacik D., Tvrdikova E., Keil C., Haase H., Adam V., Heger Z. (2019) Sarcosine is a prostate epigenetic modifier that elicits aberrant methylation patterns through the SAMe-Dnmts axis. Molecular Oncology. 13, 1002-1017.

IF 5,962

10) Indra R., Cerna T., Heger Z., Hrabeta J., Wilhelm M., Dostalova S., Lengalova A., Martinkova M., Adam V., Eckschlager T., Schmeiser H. H., Arlt V. M., Stiborova M. (2019) Ellipticine-loaded apoferritin nanocarrier retains DNA adduct-based cytochrome P450-facilitated toxicity in neuroblastoma cells. Toxicology. 419, 40-54.

IF 3,547

11) Beladi-Mousavi S. M., Khezri B., Krejcova L., Heger Z., Sofer Z., Fisher A. C., Pumera M. (2019) Recoverable bismuth-based microrobots: Capture, transport, and on-demand release of heavy metals and an anticancer drug in confined spaces. ACS Applied Materials & Interfaces. 11, 13359- 13369.

IF 8,456

12) Strmiska V., Michalek P., Eckschlager T., Stiborova M., Adam V., Krizkova S., Heger Z. (2019) Prostate cancer-specific hallmarks of amino acids metabolism: Towards a paradigm of precision medicine. Biochimica et Biophysica Acta-Reviews on Cancer. 1871, 248-258.

IF 6,887

13) Tesarova B., Charousova M., Dostalova S., Bienko A., Kopel P., Kruszynski R., Hynek D., Michalek P., Eckschlager T., Stiborova M., Adam V., Heger Z. (2019) Folic acid-mediated re- shuttling of ferritin receptor specificity towards a selective delivery of highly cytotoxic nickel(II) coordination compounds. International Journal of Biological Macromolecules. 126, 1099-1111.

IF 4,784

14) Vanickova L., Guran R., Kollar S., Emri G., Krizkova S., Do T., Heger Z., Zitka O., Adam V. (2019) Mass spectrometric imaging of cysteine rich proteins in human skin. International Journal of Biological Macromolecules. 125, 270-277.

IF 4,784

15) Rodrigo M. A. M., Buchtelova H., Jimenez A. M. J., Adam P., Babula P., Heger Z., Adam V. (2019) Transcriptomic landscape of cisplatin-resistant neuroblastoma cells. Cells. 8, art. no. 235.

IF 5,656

(3)

16) Rodrigo M. A. M., Buchtelova H., de los Rios V., Casal J. I., Eckschlager T., Hrabeta J., Belhajova M., Heger Z., Adam V. (2019) Proteomic signature of neuroblastoma cells UKF-NB-4 reveals a key role of lysosomal sequestration and the proteasome complex in acquiring chemoresistance to cisplatin. Journal of Proteome Research. 18, 1255-1263.

IF 3,780

17) Peskova M., Ilkovics L., Hynek D., Dostalova S., Sanchez-Carnerero E. M., Remes M., Heger Z., Pekarik V. (2019) Detergent-modified catalytic and enzymomimetic activity of silver and palladium nanoparticles biotemplated by Pyrococcus furiosus ferritin. Journal of Colloid and Interface Science. 537, 20-27.

IF 6,361

18) Buchtelova H., Skubalova Z., Strmiska V., Michalek P., Kociova S., Smerkova K., Kruszynski R., Bienko A., Kaj M., Lewinska A., Bienko A., Malik-Gajewska M., Milosavljevic V., Kopel P., Heger Z., Adam V. (2019) Synthesis and structural characterization of antimicrobial binuclear copper (II) coordination compounds bridged by hydroxy- and/or thiodipropionic acid. Journal of Inorganic Biochemistry. 191, 8-20.

IF 3,224

19) Khezri B., Mousavi S. M. B., Krejcova L., Heger Z., Sofer Z., Pumera M. (2019) Ultrafast electrochemical trigger drug delivery mechanism for nanographene micromachines. Advanced Functional Materials. 24, art. no. 1806696.

IF 15,621

20) Michalkova H., Strmiska V., Kudr J., Skubalova Z., Tesarova B., Svec P., Zitka O., Adam V., Heger Z. (2019) Tuning the surface coating of IONs toward efficient sonochemical tethering and sustained liberation of topoisomerase II poisons. International Journal of Nanomedicine. 14, 7609-7624.

IF 4,471

21) Gumulec J., Raudenska M., Pacik D., Plevova M., Sorokac-Kubolkova A., Lackova Z., Cernei N., Strmiska V., Zitka O., Heger Z., Adam V. (2018) Post-treatment urinary sarcosine as a predictor of recurrent relapses in patients with prostate cancer. Cancer Medicine. 7, 5411-5419.

IF 3,357

22) Moulick A., Heger Z., Milosavljevic V., Richtera L., Barroso-Flores J., Rodrigo M. A. M., Buchtelova H., Podgajny R., Hynek D., Kopel P., Adam V. (2018) Real-time visualization of cell membrane damage using gadolinium-Schiff base complex-doped quantum dots. ACS Applied Materials & Interfaces. 10, 35859-35868.

IF 8,456

23) Villa K., Krejcova L., Novotny F., Heger Z., Sofer Z., Pumera M. (2018) Cooperative multifunctional self-propelled paramagnetic microrobots with chemical handles for cell manipulation and drug delivery. Advanced Functional Materials. 28, art. no. 1804343.

IF 15,621

24) Peskova M., Heger Z., Dostalova S., Fojtu M., Castkova K., Ilkovics L., Vykoukal V., Pekarik V.

(2018) Investigation of detergent-modified enzymomimetic activities of TEMED-templated nanoceria towards fluorescent detection of their cellular uptake. ChemistrySelect. 3, 10139-10146.

IF 1,716

25) Milosavljevic V., Haddad Y., Moulick A., Buchtelova H., Guran R., Pospisil T., Stokowa-Soltys K., Heger Z., Richtera L., Kopel P., Adam V. (2018) Functional analysis of Novicidin peptide:

Coordinated delivery system for zinc via Schiff base ligand. Bioconjugate Chemistry. 29, 2954- 2969.

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IF 4,349

26) Dostalova S., Polanska H., Svobodova M., Balvan J., Krystofova O., Haddad Y., Krizkova S., Masarik M., Eckschlager T., Stiborova M., Heger Z., Adam V. (2018) Prostate-specific membrane antigen-targeted site-directed antibody-conjugated apoferritin nanovehicle favorably influences in vivo side effects of doxorubicin. Scientific Reports. 8, art. no. 8867.

IF 4,011

27) Buchtelova H., Strmiska V., Skubalova Z., Dostalova S., Michalek P., Krizkova S., Hynek D., Kalina L., Richtera L., Moulick A., Adam V., Heger Z. (2018) Improving cytocompatibility of CdTe quantum dots by Schiff-base-coordinated lanthanides surface doping. Journal of Nanobiotechnology. 16, art. no. 43.

IF 5,345

28) Jimenez A. M. J., Moulick A., Richtera L., Krejcova L., Kalina L., Datta R., Svobodova M., Hynek D., Masarik M., Heger Z., Adam V. (2018) Dual-color quantum dots-based simultaneous detection of HPV-HIV co-infection. Sensors and Actuators B-Chemical. 258, 295-303.

IF 6,393

29) Pacik D., Plevova M., Urbanova L., Lackova Z., Strmiska V., Necas A., Heger Z., Adam V. (2018) Identification of sarcosine as a target molecule for the canine olfactory detection of prostate cancer. Scientific Reports. 8, art. no. 4958.

IF 4,011

30) Krizkova S., Kepinska M., Emri G., Eckschlager T., Stiborova M., Pokorna P., Heger Z., Adam V.

(2018) An insight into the complex roles of metallothioneins in malignant diseases with emphasis on (sub)isoforms/isoforms and epigenetics phenomena. Pharmacology & Therapeutics. 183, 90- 117.

IF 9,396

31) Duskova K., Vesely S., Silva J. D., Cernei N., Zitka O., Heger Z., Adam V., Havlova K., Babjuk M.

(2018) Differences in urinary amino acid patterns in individuals with different types of urological tumors. In Vivo. 32, 425-429.

IF 1,609

32) Rodrigo M. A. M., Strmiska V., Horackova E., Buchtelova H., Michalek P., Stiborova M., Eckschlager T., Adam V., Heger Z. (2018) Sarcosine influences apoptosis and growth of prostate cells via cell-type specific regulation of distinct sets of genes. Prostate. 78, 104-112.

IF 2,876

33) Rodrigo M. A. M., Dostalova S., Buchtelova H., Strmiska V., Michalek P., Krizkova S., Vicha A., Jencova P., Eckschlager T., Stiborova M., Heger Z., Adam V. (2018) Comparative gene expression profiling of human metallothionein-3 up-regulation in neuroblastoma cells and its impact on susceptibility to cisplatin. Oncotarget. 9, 4427-4439.

IF 5,168

34) Kolarik M., Indra R., Adam V., Heger Z., Kopeckova K., Arlt V. M., Stiborova M. (2018) Tyrosine kinase inhibitors vandetanib, lenvatinib and cabozantinib modulate oxidation of an anticancer agent ellipticine catalysed by cytochrome P450 in vitro. Neuroendocrinology Letters. 39, 515- 524.

IF 0,698

35) Jelinkova P., Splichal Z., Jimenez A. M. J., Haddad Y., Mazumdar A., Sur V. P., Milosavljevic V., Kopel P., Buchtelova H., Guran R., Zitka O., Richtera L., Hegerova D., Heger Z., Moulick A., Adam V. (2018) Infection and Drug Resistance. 11, 1807-1817.

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IF 3,000

36) Guran R., Vanickova L., Horak V., Krizkova S., Michalek P., Heger Z., Zitka O., Adam V. (2017) MALDI MSI of MeLiM melanoma: Searching for differences in protein profiles. PLoS One. 12, art. no. e0189305.

IF 2,776

37) Stiborova M., Indra R., Frei E., Kopeckova K., Schmeiser H. H., Eckschlager T., Adam V., Heger Z., Arlt V. M., Martinek V. (2017) Cytochrome b(5) plays a dual role in the reaction cycle of cytochrome P450 3A4 during oxidation of the anticancer drug ellipticine. Monatshefte fur Chemie. 148, 1983-1991.

IF 1,501

38) Haddad Y., Dostalova S., Kudr J., Zitka O., Heger Z. Adam V. (2017) DNA-magnetic particle binding analysis by dynamic and electrophoretic light scattering. JOVE-Journal of Visualized Experiments. 129, UNSP e56815.

IF 1,108

39) Buchtelova H., Strmiska V., Dostalova S., Michalek P., Krizkova S., Kopel P., Hynek D., Richtera L., Adam V., Heger Z. (2017) pH-responsive hybrid organic-inorganic ruthenium nanoparticles for controlled release of doxorubicin. Particle & Particle Systems Characterization. 34, art. no.

1700289.

IF 4,194

40) Pekarik V., Peskova M., Guran R., Novacek J., Heger Z., Tripsianes K., Kumar J., Adam V. (2017) Visualization of stable ferritin complexes with palladium, rhodium and iridium nanoparticles detected by their catalytic activity in native polyacrylamide gels. Dalton Transactions. 46, 13690- 13694.

IF 4,052

41) Lackova Z., Buchtelova H., Buchtova Z., Klejdus B., Heger Z., Brtnicky M., Kynicky J., Zitka O., Adam V. (2017) Anticarcinogenic effect of spices due to phenolic and flavonoid compounds-in vitro evaluation of prostate cells. Molecules. 22, art. no. 1626.

IF 3,060

42) Svobodova M., Raudenska M., Gumulec J., Balvan J., Fojtu M., Kratochvilova M., Polanska H., Horakova Z., Kostrica R., Babula P., Heger Z., Masarik M. (2017) Establishment of oral squamous cell carcinoma cell line and magnetic bead-based isolation and characterization of its CD90/CD44 subpopulations. Oncotarget. 8, 66254-66269.

IF 5,168

43) Kudr J., Haddad Y., Richtera L., Heger Z., Cernak M., Adam V., Zitka O. (2017) Magnetic nanoparticles: From design and synthesis to real world applications. Nanomaterials. 7, art. no.

243.

IF 4,034

44) Moulick A., Richtera L., Milosavljevic V., Cernei N., Haddad Y., Zitka O., Kopel P., Heger Z., Adam V. (2017) Advanced nanotechnologies in avian influenza: Current status and future trends – A review. Analytica Chimica Acta. 983, 42-53.

IF 5,256

45) Milosavljevic V., Krejcova L., Guran R., Buchtelova H., Wawrzak D., Richtera L., Heger Z., Kopel P., Adam V. (2017) Exceptional release kinetics and cytotoxic selectivity of oxidised MWCNTs double-functionalised with doxorubicin and prostate-homing peptide. Colloids and Surfaces B- Biointerfaces. 182, 123-132.

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IF 3,973

46) Buchtelova H., Dostalova S., Michalek P., Krizkova S., Strmiska V., Kopel P., Hynek D., Richtera L., Ridoskova A., Adam P., Kynicky J., Brtnicky M., Heger Z., Adam V. (2017) Size-related cytotoxicological aspects of polyvinylpyrrolidone-capped platinum nanoparticles. Food and Chemical Toxicology. 105, 337-346.

IF 3,775

47) Hegerova D., Vesely R., Cihalova K., Kopel P., Milosavljevic V., Heger Z., Hynek D., Guran R., Vaculovicova M., Sedlacek P., Adam V. (2017) Antimicrobial agent based on selenium nanoparticles and carboxymethyl cellulose for the treatment of bacterial infections. Journal of Biomedical Nanotechnology. 13, 767-777.

IF 5,068

48) Kudr J., Richtera L., Xhaxhiu K., Hynek D., Heger Z., Zitka O., Adam V. (2017) Carbon dots based FRET for the detection of DNA damage. Biosensors & Bioelectronics. 92, 133-139.

IF 9,518

49) Cardova A., Adam P., Mariani S., Richtera L., Heger Z., Labuda J., Minunni M., Adam V. (2017) Electrochemical and optical study of metallothionein interactions with prion proteins. Journal of Pharmaceutical and Biomedical Analysis. 140, 355-361.

IF 2,983

50) Haddad Y., Adam V., Heger Z. (2017) TrK receptors and neurotrophin cross-interactions: New perspectives toward manipulating therapeutic side-effects. Frontiers in Molecular Neuroscience.

10, art. no. 130.

IF 3,720

51) Kratochvilova M., Raudenska M., Heger Z., Richtera L., Cernei N., Adam V., Babula P., Novakova M., Masarik M., Gumulec J. (2017) Amino acid profiling of zinc resistant prostate cancer cell lines: Associations with cancer progression. Prostate. 77, 604-616.

IF 2,876

52) Jimenez A. M. J., Rodrigo M. A. M., Milosavljevic V., Krizkova S., Kopel P., Heger Z., Adam V.

(2017) Gold nanoparticles-modified nanomaghemite and quantum dots-based hybridization assay for detection of HPV. Sensors and Actuators B-Chemical. 240, 503-510.

IF 6,393

53) Peskova M., Heger Z., Janda P., Adam V., Pekarik V. (2017) An enzymatic assay based on luciferase Ebola virus-like particles for evaluation of virolytic activity of antimicrobial peptides. Peptides.

88, 87-96.

IF 2,659

54) Heger Z., Polanska H., Krizkova S., Balvan J., Raudenska M., Dostalova S., Moulick A., Masarik M., Adam V. (2017) Co-delivery of VP-16 and Bcl-2-targeted antisense on PEG-grafted oMWCNTs for synergistic in vitro anti-cancer effects in non-small and small cell lung cancer.

Colloids and Surfaces B-Biointerfaces. 150, 131-140.

IF 3,973

55) Haddad Y., Heger Z., Adam V. (2017) Targeting neuroblastoma cell surface proteins:

Recommendations for homology modeling of hNET, ALK, and TrKB. Frontiers in Molecular Neuroscience. 10, art. no. 7.

IF 3,720

(7)

56) Anyz J., Vyslouzilova L., Vaculovic T., Tvrdonova M., Kanicky V., Haase H., Horak V., Stepankova O., Heger Z., Adam V. (2017) Spatial mapping of metals in tissue-sections using combination of mass-spectrometry and histology through image registration. Scientific Reports.

7, art. no. 40169.

IF 4,011

57) Milosavljevic V., Jelinkova P., Jimenez A. M. J., Moulick A., Haddad Y., Buchtelova H., Krizkova S., Heger Z., Kalina L., Richtera L., Kopel P., Adam V. (2017) Alternative synthesis route of biocompatible polyvinylpyrrolidone nanoparticles and their effect on pathogenic microorganisms.

Molecular Pharmaceutics. 14, 221-233.

IF 4,396

58) Rodrigo M. A. M., Krejcova L., Kudr J., Cernei N., Kopel P., Richtera L., Moulick A., Hynek D., Adam V., Stiborova M., Eckschlager T., Heger Z., Zitka O. (2016) Fully automated two-step assay for detection of metallothionein through magnetic isolation using functionalized gamma- Fe2O3 particles. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 1039, 17-27.

IF 2,813

59) Heger Z., Rodrigo M. A. M., Michalek P., Polanska H., Masarik M., Vit V., Plevova M., Pacik D., Eckschlager T., Stiborova M., Adam V. (2016) Sarcosine up-regulates expression of genes involved in cell cycle progression of metastatic models of prostate cancer. PLoS One. 11, art. no.

e0165830.

IF 2,776

60) Haddad Y., Heger Z., Adam V. (2016) Guidelines for homology modeling of dopamine, norepinephrine, and serotonin transporters. ACS Chemical Neuroscience. 7, 1607-1613.

IF 3,861

61) Hrabeta J., Eckschlager T., Stiborova M., Heger Z., Krizkova S., Adam V. (2016) Zinc and zinc- containing biomolecules in childhood brain tumors. Journal of Molecular Medicine. 94, 1199- 1215.

IF 4,746

62) Anjum N. A., Rodrigo M. A. M., Moulick A., Heger Z., Kopel P., Zitka O., Adam V., Lukatkin A.

S., Duarte A. C., Pereira E., Kizek R. (2016) Transport phenomena of nanoparticles in plants and animals/humans. Environmental Research. 151, 233-243.

IF 5,026

63) Milosavljevic V., Haddad Y., Rodrigo M. A. M., Moulick A., Polanska H., Hynek D., Heger Z., Kopel P., Adam V. (2016) The zinc-Schiff base-novidicin complex as a potential prostate cancer therapy. PLoS One. 11, art. no. e0163983.

IF 2,776

64) Rodrigo M. A. M., Krejcova L., Heger Z., Zitka O., Adam V., Kizek R. (2016) Electrochemical microarray as a rapid tool for identification of mutations in influenza virus genes. International Journal of Electrochemical Science. 10, 9952-9967.

65) Heger Z., Polanska H., Rodrigo M. A. M., Guran R., Kulich P., Kopel P., Masarik M., Eckschlager T., Stiborova M., Kizek R., Adam V. (2016) Prostate tumor attenuation in the nu/nu murine model due to anti-sarcosine antibodies in folate-targeted liposomes. Scientific Reports. 6, art. no. 33379.

IF 4,011

66) Polanska H., Raudenska M., Hudcova K., Gumulec J., Svobodova M., Heger Z., Fojtu M., Binkova H., Horakova Z., Kostrica R., Adam V., Kizek R., Masarik M. (2016) Evaluation of EGFR as a

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prognostic and diagnostic marker for head and neck squamous cell carcinoma patients. Oncology Letters. 12, 2127-2132.

IF 1,871

67) Michalek P., Richtera L., Krejcova L., Nejdl L., Kensova R., Zitka J., Kopel P., Heger Z., Adam V., Kizek R. (2016) Bioconjugation of peptides using advanced nanomaterials to examine their interactions in 3D printed flow-through device. Electrophoresis. 37, 444-454.

IF 2,754

68) Dostalova S., Cerna T., Hynek D., Koudelkova Z., Vaculovic T., Kopel P., Hrabeta J., Heger Z., Vaculovicova M., Eckschlager T., Stiborova M., Adam V. (2016) Site-directed conjugation of antibodies to apoferritin nanocarrier for targeted drug delivery to prostate cancer cells. ACS Applied Materials & Interfaces. 8, 14430-14441.

IF 8,456

69) Molina-Lopez J., del Pozo E. P., Florea D. I., Fernandez C., Osso B. Q., Zalewska M., Krizkova S., Heger Z., Kizek R., Adam V. (2016) Nutritional and methodological perspectives of zinc ions and complexes – physiological and pathological states. International Journal of Electrochemical Science. 11, 4470-4496.

IF 1,284

70) Heger Z., Kominkova M., Zitka O., Beklova M., Adam V., Kizek R. (2016) Rapid distinguishing between rhodium and palladium in highly contaminated waters using amperometry. International Journal of Electrochemical Science. 11, 4645-4657.

IF 1,284

71) Polanska H., Heger Z., Gumulec J., Raudenska M., Svobodova M., Balvan J., Fojtu M., Binkova H., Horakova Z., Kostrica R., Adam V., Kizek R., Masarik M. (2016) Effect of HPV on tumor expression levels of the most commonly used markers in HNSCC. Tumor Biology. 37, 7193-7201.

IF 3,650

72) Heger Z., Gumulec J., Cernei N., Polanska H., Raudenska M., Masarik M., Eckschlager T., Stiborova M., Adam V., Kizek R. (2016) Relation of exposure to amino acids involved in sarcosine metabolic pathway on behavior of non-tumor and malignant prostatic cell lines.

Prostate. 76, 679-690.

IF 2,876

73) Heger Z., Zitka J., Nejdl L., Moulick A., Milosavljevic V., Kopel P., Zavodsky O., Kapus J., Lenza L., Rezka M., Adam V., Kizek R. (2016) 3D printed stratospheric probe as a platform for determination of DNA damage based on carbon quantum dots/DNA complex fluorescence increase. Monatshefte fur Chemie. 147, 873-880.

IF 1,501

74) Dostalova S., Moulick A., Milosavljevic V., Guran R., Kominkova M., Cihalova K., Heger Z., Blazkova I., Kopel P., Hynek D., Vaculovicova M., Adam V., Kizek R. (2016) Antiviral activity of fullerene C-60 nanocrystals modified with derivatives of anionic antimicrobial peptide maximin H5. Monatshefte fur Chemie. 147, 905-918.

IF 1,501

75) Vesely R., Jelinkova P., Hegerova D., Cernei N., Kopel P., Moulick A., Richtera L., Heger Z., Adam V., Zitka O. (2016) Nanoparticles suitable for BCAA isolation can serve for use in magnetic lipoplex-based delivery system for L, I, V, or R-rich antimicrobial peptides. Materials. 9, art. no.

260.

IF 2,972

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76) Heger Z., Gumulec J., Ondrak A., Skoda J., Zitka Z., Cernei N., Masarik M., Zitka O., Adam V.

(2016) Influence of long-distance bicycle riding on serum/urinary biomarkers of prostate cancer.

International Journal of Molecular Sciences. 17, art. no. 377.

IF 4,183

77) Heger Z., Rodrigo M. A. M., Krizkova S., Ruttkay-Nedecky B., Zalewska M., del Pozo E. M. P., Pelfrene A., Pourrut B., Stiborova M., Eckschlager T., Emri G., Kizek R., Adam V. (2016) Metallothionein as a scavenger of free radicals – New cardioprotective therapeutic agent or initiator of tumor chemoresistance? Current Drug Targets. 17, 1438-1451.

IF 2,642

78) Nguyen H. V., Richtera L., Moulick A., Xhaxhiu K., Kudr J., Cernei N., Polanska H., Heger Z., Masarik M., Kopel P., Stiborova M., Eckschlager T., Adam V., Kizek R. (2016) Electrochemical sensing of etoposide using carbon quantum dot modified glassy carbon electrode. Analyst. 141, 2665-2675.

IF 4,019

79) Adam P., Krizkova S., Heger Z., Babula P., Pekarik V., Vaculovicova M., Gomes C. M., Kizek R.

Adam V. (2016) Metallothioneins in prion- and amyloid-related diseases. Journal of Alzheimer Disease. 51, 637-656.

IF 3,517

80) Heger Z., Michalek P., Guran R., Havelkova B., Kominkova M., Cernei N., Richtera L., Beklova M., Adam V., Kizek R. (2015) Exposure to 17 beta-oestradiol induces oxidative stress in non- oestrogen receptor invertebrate species Eisenia fetida. PLoS One. 10, art. no. e0145426.

IF 2,776

81) Heger Z., Michalek P., Guran R., Cernei N., Duskova K., Vesely S., Anyz J., Stepankova O., Zitka O., Adam V., Kizek R. (2015) Differences in urinary proteins related to surgical margin status after radical prostatectomy. Oncology Reports. 34, 3247-3255.

IF 3,041

82) Chudobova D., Cihalova K., Guran R., Dostalova S., Smerkova K., Vesely R., Gumulec J., Masarik M., Heger Z., Adam V., Kizek R. (2015) Influence of microbiome species in hard-to-heal wounds on disease severity and treatment duration. Brazilian Journal of Infectious Diseases. 19, 604-613.

IF 2,223

83) Tmejova K., Hynek D., Kopel P., Gumulec J., Krizkova S., Guran R., Heger Z., Kalina M., Vaculovicova M., Adam V., Kizek R. (2015) Structural effects and nanoparticle size are essential for quantum dots-metallothionein complex formation. Colloids and Surfaces B-Biointerfaces.

134, 262-272.

IF 3,973

84) Skalickova S., Heger Z., Krejcova L., Pekarik V., Bastl K., Janda J., Kostolansky F., Vareckova E., Zitka O., Adam V., Kizek R. (2015) Perspective of use of antiviral peptides against influenza virus. Viruses-Basel. 7, 5428-5442.

IF 3,811

85) Fernandez C., Heger Z., Kizek R., Ramakrishnappa T., Borun A., Faisal N. H. (2015) Pharmaceutical electrochemistry: The electrochemical oxidation of paracetamol and its voltammetric sensing in biological samples based on screen printed graphene electrodes.

International Journal of Electrochemical Science. 10, 7440-7452.

IF 1,284

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86) Heger Z., Moulick A., Nguyen H. V., Kremplova M., Kopel P., Hynek D., Eckschlager T., Stiborova M., Zitka O., Adam V., Kizek R. (2015) Characterization of multi-walled carbon nanotubes double-functionalized with cytostatic drug etoposide and phosphorothioate oligodeoxynucleotides. International Journal of Electrochemical Science. 10, 7707-7719.

IF 1,284

87) Nejdl L., Nguyen H. V., Richtera L., Krizkova S., Guran R., Masarik M., Hynek D., Heger Z., Lundberg K., Erikson K., Adam V., Kizek R. (2015) Label-free bead-based metallothionein electrochemical immunosensor. Electrophoresis. 36, 1894-1904.

IF 2,754

88) Heger Z., Zitka J., Cernei N., Krizkova S., Sztalmachova M., Kopel P., Masarik M., Hodek P., Zitka O., Adam V., Kizek R. 3D-printed biosensor with poly(dimethylsiloxane) reservoir for magnetic separation and quantum dots-based immunolabeling of metallothionein. Electrophoresis. 36, 1256-1264.

IF 2,754

89) Kominkova M., Michalek P., Cihalova K., Guran R., Cernei N., Nejdl L., Smerkova K., Dostalova S., Chudobova D., Heger Z., Vesely R., Gumulec J., Kynicky J., Xhaxhiu K., Zitka O., Adam V., Kizek R. (2015) Study of linkage between glutathione pathway and the antibiotic resistance of Escherichia coli from patients´ swabs. International Journal of Molecular Sciences. 16, 7210- 7229.

IF 4,183

90) Heger Z., Cernei N., Krizkova S., Masarik M., Kopel P., Hodek P., Zitka O., Adam V., Kizek R., (2015) Paramagnetic nanoparticles as a platform for FRET-based sarcosine Picomolar detection.

Scientific Reports. 5, art. no. 8868.

IF 4,011

91) Nejdl L., Kudr J., Ruttkay-Nedecky B., Heger Z., Zima L., Zalud L., Krizkova S., Adam V., Vaculovicova M., Kizek R. (2015) Remote-controlled robotic platform for electrochemical determination of water contaminated by heavy metal ions. International Journal of Electrochemical Science. 10, 3635-3643.

IF 1,284

92) Nguyen H. V., Heger Z., Kominkova M., Michalek P., Gumulec J., Guran R., Pridal A., Fernandez C., Hynek D., Adam V., Kizek R. (2015) The electrochemical and statistical evaluation of isolation of melittin and apamin from honey bee (Apis mellifera) venom. International Journal of Electrochemical Science. 10, 1249-1260.

IF 1,284

93) Heger Z., Gumulec J., Cernei N., Tmejova K., Kopel P., Balvan J., Masarik M., Zitka O., Beklova M., Adam V., Kizek R. (2015) 17 beta-estradiol-containing liposomes as a novel delivery system for the antisense therapy of ER-positive breast cancer: An in vitro study on the MCF-7 cell line.

Oncology Reports. 33, 921-929.

IF 3,041

94) Krizkova S., Heger Z., Zalewska M., Moulick A., Adam V., Kizek R. (2015) Nanotechnologies in protein microarrays. Nanomedicine. 10, 2743-2755.

IF 4,717

95) Heger Z., Zitka O., Fohlerova Z., Rodrigo M. A. M., Hubalek J., Kizek R., Adam V. (2015) Use of green fluorescent proteins for in vitro biosensing. Chemical Papers. 69, 54-61.

IF 1,246

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96) Heger Z., Kominkova M., Cernei N., Krejcova L., Kopel P., Zitka O., Adam V., Kizek R. (2014) Fluorescence resonance energy transfer between green fluorescent protein and doxorubicin enabled by DNA nanotechnology. Electrophoresis. 35, 3290-3301.

IF 2,754

97) Heger Z., Cernei N., Blazkova I., Kopel P., Masarik M., Zitka O., Adam V., Kizek R. (2014) Gamma-Fe2O3 nanoparticles covered with glutathione-modified quantum dots as a fluorescent nanotransporter. Chromatographia. 77, 1415-1423.

IF 1,552

98) Cernei N., Heger Z., Kopel P., Skladanka J., Zitka O., Adam V., Kizek R. (2014) Isolation of biogenic amines using paramagnetic microparticles off-line coupled with ion exchange liquid chromatography. Chromatographia. 77, 1421-1459.

IF 1,552

99) Heger Z., Guran R., Zitka O., Beklova M., Adam V., Kizek R. (2014) In vitro interactions between 17 beta-estradiol and DNA result in formation of the hormone-DNA complexes. International Journal of Environmental Research and Public Health. 11, 7725-7739.

IF 2,468

100) Heger Z., Cernei N., Guran R., Michalek P., Milosavljevic V., Kopel P., Zitka O., Kynicky J., Lany P., Adam V., Kizek R. (2014) Gamma-Fe2O3 magnetic core functionalized with tetraethyl orthosilicate and 3-aminopropyl triethoxysilane for an isolation of H7N7 influenza serotype virions. International Journal of Electrochemical Science. 9, 3374-3385.

IF 1,284

101) Cernei N., Heger Z., Kopel P., Milosavljevic V., Kominkova M., Moulick A., Zitka O., Trnkova L., Adam V., Kizek R. (2014) Spectroscopic and electrochemical characterization of CD4 binding site of HIV-1 exterior envelope gp120. International Journal of Electrochemical Science. 9, 3386- 3397.

IF 1,284

102) Rodrigo M. A. M., Zitka O., Krejcova L., Hynek D., Masarik M., Kynicky J., Heger Z., Adam V., Kizek R. (2014) Electrochemical microarray for identification of pathogens: A review.

International Journal of Electrochemical Science. 9, 3431-3439.

IF 1,284

103) Rodrigo M. A. M., Heger Z., Cernei N., Jimenez A. M. J., Zitka O., Adam V., Kizek R. (2014) HIV biosensors – The potential of the electrochemical way. International Journal of Electrochemical Science. 9, 3449-3457.

IF 1,284

104) Kominkova M., Guran R., Rodrigo M. A. M., Kopel P., Blazkova I., Chudobova D., Nejdl L., Heger Z., Ruttkay-Nedecky B., Zitka O., Adam V., Kizek R. (2014) Study of functional qualities of different types of tailored liposomes with encapsulated doxorubicin using electrochemical and optical methods. International Journal of Electrochemical Science. 9, 2993-3007.

IF 1,284

105) Heger Z., Rodrigo M. A. M., Krizkova S., Zitka O., Beklova M., Kizek R., Adam V. (2014) Identification of estrogen receptor proteins in breast cancer cells using matrix-assisted laser desorption/ionization time of flight mass spectrometry. Oncology Letters. 7, 1341-1344.

IF 1,284

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106) Heger Z., Cernei N., Gumulec J., Masarik M., Eckschlager T., Hrabec R., Zitka O., Adam V., Kizek R. (2014) Determination of common urine substances as an assay for improving prostate carcinoma diagnostics. Oncology Reports. 31, 1846-1854.

IF 3,041

107) Zitka O., Heger Z., Kominkova M., Skalickova S., Krizkova S., Adam V., Kizek R. (2014) Preconcentration based on paramagnetic microparticles for the separation of sarcosine using hydrophilic interaction liquid chromatography coupled with coulometric detection. Journal of Separation Science. 37, 465-475.

IF 2,516

108) Kominkova M., Heger Z., Zitka O., Kynicky J., Pohanka M., Beklova M., Adam V., Kizek R.

(2014) Flow injection analysis with electrochemical detection for rapid identification of platinum- based cytostatics and platinum chlorides in water. International Journal of Environmental Research and Public Health. 11, 1715-1724.

IF 2,468

109) Heger Z., Skalickova S., Zitka O., Adam V., Kizek R. (2014) Apoferritin applications in nanomedicine. Nanomedicine. 9, 2233-2245.

IF 4,717

110) Heger Z., Cernei N., Kudr J., Gumulec J., Blazkova I., Zitka O., Eckschlager T., Stiborova M., Adam V., Kizek R. (2013) A novel insight into the cardiotoxicity of antineoplastic drug doxorubicin. International Journal of Molecular Sciences. 14, 21629-21646.

IF 4,183

111) Zitka O., Cernei N., Heger Z., Matousek M., Kopel P., Kynicky J., Masarik M., Kizek R., Adam V. (2013) Microfluidic chip coupled with modified paramagnetic particles for sarcosine isolation in urine. Electrophoresis. 34, 2639-2647.

IF 2,754

112) Cernei N., Heger Z., Gumulec J., Zitka O., Masarik M., Babula P., Eckschlager T., Stiborova M., Kizek R., Adam V. (2013) Sarcosine as a potential prostate cancer biomarker-A review.

International Journal of Molecular Sciences. 14, 13893-13908.

IF 4,183

113) Heger Z., Zitka O., Krizkova S., Beklova M., Kizek R., Adam V. (2013) Molecular biology of beta-estradiol-estrogen receptor complex binding to estrogen response element and the effect on cell proliferation. Neuroendocrinology Letters. 34, 123-129.

IF 0,698

Původní články v časopisech bez IF

1) Heger Z., Eckschlager T., Stiborova M., Adam V. (2016) Glycin-N-methyltransferáza a nádorová onemocnění prostaty. Klinická Onkologie. 29, 331-335.

2) Heger Z., Eckschlager T., Stiborova M., Adam V., Zitka O., Kizek R. (2015) Moderní nanomedicína v léčbě karcinomu plic. Klinická Onkologie. 28, 245-250.

3) Bastl K., Skalickova S., Heger Z., Zitka O., Adam V., Kizek R. (2015) Modeling of the antiviral peptide for specific inhibition of influenza virus entry. Journal of Drug Design and Research. 2, art. no. 1010.

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4) Heger Z., Cernei N., Gumulec J., Vesely S., Zitka O., Masarik M., Adam V., Kizek R. (2015) Změny v hladinách prolinu v moči korelovat s úspěšností operační léčby karcinomu prostaty. Praktický Lékař. 95, 31-35.

5) Cernei N., Heger Z., Vesely S., Zitka O., Adam V., Kizek R. (2014) Chromatografická charakterizace aminokyselinových profilů vzorků moči pacientů s karcinomem prostaty. Klinická Biochemie a Metabolismus. 22, 196-202.

Účast na řešení grantů Spoluřešitel či řešitel:

1) GAČR 19-13628S Enkapsulace reaktivátorů cholinesteras pomocí apoferitinu pro zvýšení biodostupnosti v centrálním nervovém systému (2019-2021)

2) GAČR 18-10251S Komplexní pohled na mechanismus působení a metabolismus inhibitorů tyrosinkinas a studium přístupů k potenciaci jejich protinádorové účinnosti (2018-2020) 3) LPR 18436 Enzymy metabolismu sarkosinu a jejich vliv na proliferaci a agresivitu maligních a benigních prostatických buněk (2016-2017)

4) LPR 2022015 Epidemiologický screening sarkosinu v moči a jeho využití pro včasnou diagnostiku nádorů prostaty (2015-2016)

5) LPR 18257/2014-981 Kombinovaná terapie nádorů plic založená na chytrých nanotechnologiích (2014-2015)

V Brně, 3. 2. 2020 Zbyněk Heger

Odkazy

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