• Nebyly nalezeny žádné výsledky

Author Contributions

In document Příloha práce (2.536Mb) (Stránka 37-41)

Conceived and designed the experiments: PK JP. Performed the experiments: LL JP TNA MK BM PV MA ED OV. Analyzed the data: JP PK MS. Wrote the paper: MS PK JP.

Fig 6. Schematic illustration of the processes associated with fludarabine resistance in Mino/FR cells summarizes the landmark observations in our analyses.

doi:10.1371/journal.pone.0135314.g006

Characterization of Fludarabine Resistant MCL Cells

PLOS ONE | DOI:10.1371/journal.pone.0135314 August 18, 2015 16 / 19

References

1. Dreyling M, Kluin-Nelemans HC, BeàS, Klapper W, Vogt N, Delfau-Larue M-H, et al. Update on the molecular pathogenesis and clinical treatment of mantle cell lymphoma: report of the 11th annual con-ference of the European Mantle Cell Lymphoma Network. Leuk Lymphoma. 2013; 54:699707. doi:

10.3109/10428194.2012.733882PMID:23020649

2. Kluin-Nelemans HC, Hoster E, Hermine O, Walewski J, Trneny M, Geisler CH, et al. Treatment of older patients with mantle-cell lymphoma. N Engl J Med. 2012; 367:520–31. doi:10.1056/NEJMoa1200920 PMID:22873532

3. Jares P, Colomer D, Campo E: Molecular pathogenesis of mantle cell lymphoma. J Clin Invest. 2012;

122:3416–23. doi:10.1172/JCI61272PMID:23023712

4. Forstpointner R, Dreyling M, Repp R, Hermann S, Hänel A, Metzner B, et al. The addition of rituximab to a combination of fludarabine, cyclophosphamide, mitoxantrone (FCM) significantly increases the response rate and prolongs survival as compared with FCM alone in patients with relapsed and refrac-tory follicular and mantle cell lymphomas: results of a prospective randomized study of the German Low-Grade Lymphoma Study Group. Blood 2004; 104:3064–71. PMID:15284112

5. Lin TS, Blum KA, Fischer DB, Mitchell SM, Ruppert AS, Porcu P, et al. Flavopiridol, fludarabine, and rituximab in mantle cell lymphoma and indolent B-cell lymphoproliferative disorders. J Clin Oncol. 2010;

28:418–23. doi:10.1200/JCO.2009.24.1570PMID:20008633

6. Gandhi V, Plunkett W. Cellular and clinical pharmacology of fludarabine. Clin Pharmacokinet. 2002;

41:93–103. PMID:11888330

7. de Campos-Nebel M, Larripa I, González-Cid M. Non-homologous end joining is the responsible path-way for the repair of fludarabine-induced DNA double strand breaks in mammalian cells. Mutat Res.

2008; 646:816. doi:10.1016/j.mrfmmm.2008.08.013PMID:18812179

8. Månsson E, Spasokoukotskaja T, Sällström J, Eriksson S, Albertioni F. Molecular and biochemical mechanisms of fludarabine and cladribine resistance in a human promyelocytic cell line. Cancer Res.

1999; 59:5956–63. PMID:10606241

9. Månsson E, Flordal E, Liliemark J, Spasokoukotskaja T, Elford H, Lagercrantz S, et al. Down-regulation of deoxycytidine kinase in human leukemic cell lines resistant to cladribine and clofarabine and increased ribonucleotide reductase activity contributes to fludarabine resistance. Biochem Pharmacol.

2003; 65:237–47. PMID:12504799

10. Mackey JR, Galmarini CM, Graham KA, Joy AA, Delmer A, Dabbagh L, et al. Quantitative analysis of nucleoside transporter and metabolism gene expression in chronic lymphocytic leukemia (CLL): identi-fication of fludarabine-sensitive and-insensitive populations. Blood 2005; 105:767–74. PMID:

15454483

11. Reiman T, Graham KA, Wong J, Belch AR, Coupland R, Young J, et al. Mechanisms of resistance to nucleoside analogue chemotherapy in mantle cell lymphoma: a molecular case study. Leukemia. 2002;

16:1886–87. PMID:12200718

12. Moussay E, Palissot V, Vallar L, Poirel HA, Wenner T, El Khoury V, et al. Determination of genes and microRNAs involved in the resistance to fludarabine in vivo in chronic lymphocytic leukemia. Mol Can-cer 2010; 9:115. doi:10.1186/1476-4598-9-115PMID:20487546

13. Al-Harbi S, Hill BT, Mazumder S, Singh K, Devecchio J, Choudhary G, et al. An antiapoptotic BCL-2 family expression index predicts the response of chronic lymphocytic leukemia to ABT-737. Blood 2011; 118:3579–90. doi:10.1182/blood-2011-03-340364PMID:21772052

14. Sharma A, Singh K, Mazumder S, Hill BT, Kalaycio M, Almasan A. BECN1 and BIM interactions with MCL-1 determine fludarabine resistance in leukemic B cells. Cell Death Dis. 2013; 4:e628. doi:10.

1038/cddis.2013.155PMID:23681223

15. de la Fuente MT, Casanova B, Cantero E, Hernández del Cerro M, Garcia-Marco J, Silva A, et al.

Involvement of p53 in alpha4beta1 integrin-mediated resistance of B-CLL cells to fludarabine. Biochem Biophys Res Commun. 2003; 311:70812. PMID:14623330

16. Zenz T, Häbe S, Denzel T, Mohr J, Winkler D, Bühler A, et al. Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p dele-tion, TP53 mutadele-tion, p53-p21 dysfuncdele-tion, and miR34a in a prospective clinical trial. Blood 2009;

114:258997. doi:10.1182/blood-2009-05-224071PMID:19643983

17. Messina M, Del Giudice I, Khiabanian H, Rossi D, Chiaretti S, Rasi S, et al. Genetic lesions associated with chronic lymphocytic leukemia chemo-refractoriness. Blood 2014; 123:2378–88. doi:10.1182/

blood-2013-10-534271PMID:24550227

18. Rossi D, Fangazio M, Rasi S, Vaisitti T, Monti S, Cresta S, et al. Disruption of BIRC3 associates with flu-darabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia. Blood 2012;

119:2854–62. doi:10.1182/blood-2011-12-395673PMID:22308293

Characterization of Fludarabine Resistant MCL Cells

PLOS ONE | DOI:10.1371/journal.pone.0135314 August 18, 2015 17 / 19

19. Sharma A, Janocha AJ, Hill BT, Smith MR, Erzurum SC, Almasan A. Targeting mTORC1-mediated metabolic addiction overcomes fludarabine resistance in malignant B cells. Mol Cancer Res. 2014;

12:120515. doi:10.1158/1541-7786.MCR-14-0124PMID:25061101

20. Austen B, Skowronska A, Baker C, Powell JE, Gardiner A, Oscier D, et al. Mutation status of the resid-ual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion. J Clin Oncol. 2007; 25:5448–

57. PMID:17968022

21. Lai R, McDonnell TJ, O'Connor SL, Medeiros LJ, Oudat R, Keating M, et. al. Establishment and charac-terization of a new mantle cell lymphoma cell line, Mino. Leuk Res. 2002; 26:84955. PMID:12127561 22. Wiśniewski JR, Zougman A, Nagaraj N, Mann M. Universal sample preparation method for proteome

analysis. Nat Methods 2009; 6:359–62. doi:10.1038/nmeth.1322PMID:19377485

23. Brosch M, Yu L, Hubbard T, Choudhary J. Accurate and sensitive peptide identification with Mascot Percolator. J Proteome Res. 2009; 8:3176–81. doi:10.1021/pr800982sPMID:19338334

24. Ong SE, Blagoev B, Kratchmarova I, Kristensen DB, Steen H, Pandey A, et al. Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics.

Mol Cell Proteomics 2002; 1:37686. PMID:12118079

25. Arnér ES, Eriksson S. Mammalian deoxyribonucleoside kinases. Pharmacol Ther. 1995; 67:155–86.

PMID:7494863

26. Bai L, Yamaguchi M, Tatsumi M, Kon K, Bräutigam M. Mechanisms responsible for resistance of sub-lines derived from leukemia cell sub-lines to an antitumor agent 9-beta-D-arabinofuranosyl-2-fluoroadenine.

J Cancer Res Clin Oncol. 1998; 124:367–73. PMID:9719499

27. Lotfi K, Månsson E, Spasokoukotskaja T, Pettersson B, Liliemark J, Peterson C. et al. Biochemical pharmacology and resistance to 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine, a novel analogue of cla-dribine in human leukemic cells. Clin Cancer Res. 1999; 5:243844. PMID:10499616

28. Qin T, Castoro R, El Ahdab S, Jelinek J, Wang X, Si J, et al. Mechanisms of resistance to decitabine in the myelodysplastic syndrome. PLoS One 2011; 6:e23372. doi:10.1371/journal.pone.0023372PMID:

21858090

29. Klanova M, Lorkova L, Vit O, Maswabi B, Molinsky J, Pospisilova J, et al. Downregulation of deoxycyti-dine kinase in cytarabine-resistant mantle cell lymphoma cells confers cross-resistance to nucleoside analogs gemcitabine, fludarabine and cladribine, but not to other classes of anti-lymphoma agents. Mol Cancer 2014; 13:159. doi:10.1186/1476-4598-13-159PMID:24972933

30. Natsumeda Y, Prajda N, Donohue JP, Glover JL, Weber G: Enzymic capacities of purine de novo and salvage pathways for nucleotide synthesis in normal and neoplastic tissues. Cancer Res. 1984;

44:2475–9. PMID:6327016

31. Austin WR, Armijo AL, Campbell DO, Singh AS, Hsieh T, Nathanson D, et al. Nucleoside salvage path-way kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress. J Exp Med. 2012; 209:221528. doi:10.1084/jem.20121061PMID:23148236

32. Heale JT, Ball AR Jr, Schmiesing JA, Kim JS, Kong X, Zhou S, et al. Condensin I interacts with the PARP-1-XRCC1 complex and functions in DNA single-strand break repair. Mol Cell. 2006; 21:83748.

PMID:16543152

33. Li P, Jin H, Yu HG. Condensin suppresses recombination and regulates double-strand break process-ing at the repetitive ribosomal DNA array to ensure proper chromosome segregation durprocess-ing meiosis in budding yeast. Mol Biol Cell. 2014; 25:2934–47. doi:10.1091/mbc.E14-05-0957PMID:25103240 34. Constantinou A. Rescue of replication failure by Fanconi anaemia proteins. Chromosoma 2012;

121:21–36. doi:10.1007/s00412-011-0349-2PMID:22057367

35. Smith SC, Petrova AV, Madden MZ, Wang H, Pan Y, Warren MD, et al. A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress response. Nucleic Acids Res. 2014;

42:1151727. doi:10.1093/nar/gku840PMID:25217585

36. Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993; 74:60919. PMID:8358790

37. Reed JC. Balancing cell life and death: bax, apoptosis, and breast cancer. J Clin Invest. 1996;

97:24034. PMID:8647929

38. Reed JC. Bcl-2 family proteins: regulators of apoptosis and chemoresistance in hematologic malignan-cies. Semin Hematol. 1997; 34:919.

39. Souers AJ, Leverson JD, Boghaert ER, Ackler SL, Catron ND, Chen J, et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med. 2013; 19:202–8.

doi:10.1038/nm.3048PMID:23291630

40. Saba N, Wiestner A. Do mantle cell lymphomas have an 'Achilles heel'? Curr Opin Hematol. 2014;

21:350–7. doi:10.1097/MOH.0000000000000057PMID:24857884

Characterization of Fludarabine Resistant MCL Cells

PLOS ONE | DOI:10.1371/journal.pone.0135314 August 18, 2015 18 / 19

41. Wang ML, Rule S, Martin P, Goy A, Auer R, Kahl BS, et al. Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma. N Engl J Med. 2013; 369:507–16. doi:10.1056/NEJMoa1306220 PMID:23782157

42. Satterthwaite AB, Witte ON. The role of Bruton's tyrosine kinase in B-cell development and function: a genetic perspective. Immunol Rev. 2000; 175:1207. PMID:10933597

43. Cinar M, Hamedani F, Mo Z, Cinar B, Amin HM, Alkan S. Bruton tyrosine kinase is commonly overex-pressed in mantle cell lymphoma and its attenuation by Ibrutinib induces apoptosis. Leuk Res. 2013;

37:1271–7. doi:10.1016/j.leukres.2013.07.028PMID:23962569

44. Seda V, Mraz M. B-cell receptor signalling and its crosstalk with other pathways in normal and malig-nant cells. Eur J Haematol. 2015.

45. Cyster JG, Goodnow CC. Protein tyrosine phosphatase 1C negatively regulates antigen receptor sig-naling in B lymphocytes and determines thresholds for negative selection. Immunity 1995; 2:13–24.

PMID:7600299

46. Vié N, Copois V, Bascoul-Mollevi C, Denis V, Bec N, Robert B, et al. Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells.

Mol Cancer 2008; 7:14. doi:10.1186/1476-4598-7-14PMID:18221502

47. Florczyk U, Golda S, Zieba A, Cisowski J, Jozkowicz A, Dulak J. Overexpression of biliverdin reductase enhances resistance to chemotherapeutics. Cancer Lett. 2011; 300:407. doi:10.1016/j.canlet.2010.

09.003PMID:20934804

48. Kim SS, Seong S, Lim SH, Kim SY. Biliverdin reductase plays a crucial role in hypoxia-induced che-moresistance in human glioblastoma. Biochem Biophys Res Commun. 2013; 440:658–63. doi:10.

1016/j.bbrc.2013.09.120PMID:24113378

49. Tew KD. Glutathione-associated enzymes in anticancer drug resistance. Cancer Res. 1994; 54:4313–

20. PMID:8044778

50. Yao P, Fox PL. Aminoacyl-tRNA synthetases in medicine and disease. EMBO Mol Med. 2013; 5:332–

43. doi:10.1002/emmm.201100626PMID:23427196

Characterization of Fludarabine Resistant MCL Cells

PLOS ONE | DOI:10.1371/journal.pone.0135314 August 18, 2015 19 / 19

Appendix 4

Type: Journal Article

Author: Klanova, M., Lorkova, L., Vit, O., Maswabi, B., Molinsky, J., Pospisilova, J., Vockova P., Mavis, C., Lateckova, L., Kulvait, V., Vejmelkova, D., Jaksa, R.,Hernandez, F., Trneny, M.,Vokurka, M., Petrak, J., Klener, P., Jr.

Year: 2014

Title: Downregulation of deoxycytidine kinase in cytarabine-resistant mantle cell lymphoma cells

In document Příloha práce (2.536Mb) (Stránka 37-41)